SCOTUS Decision on Bowman v. Monsanto Co.

Today the Supreme Court of the United States ruled on the Bowman v. Monsanto Co. case in favor of Monsanto. The Atlantic described the case as a story about technology and innovation and investment, about legal standards and appellate precedent and statutory intent, about the nature of nature and how the law ought to answer the basic question of who owns the rights to the seeds of planted seeds“.  The case centers around 75 year old* Indiana soybean farmer Vernon Hugh Bowman, and his decision to plant a second crop of soybeans. Below is a brief overview of the case and some of the implications of the verdict.

*(every article about this case needs to point out his age)

Background Information

Obligatory file photo showing a farmer holding Monsanto's Roundup Ready Soybean seeds (AP Photo/Dan Gill, File)

Obligatory file photo showing a farmer holding Monsanto’s Roundup Ready Soybean seeds (AP Photo/Dan Gill, File)

For a thorough and legalese heavy primer on the case, read the summary put together by the Cornell University Law School, here, for a less technical primer, continue reading. Mr. Bowman had originally purchased Monsanto’s Roundup Ready Soybeans and planted them as his main crop in the spring. When a farmer buys seed for planting (genetically engineered or not), that seed usually has a contract associated with it that says that the farmer can not replant the harvested grain, Mr. Bowman signed that standard licensing agreement. Up until this point everything is on the straight and narrow, but then Mr. Bowman decided to plant his second crop of soybeans later that year, but he didn’t want to pay for Monsanto’s seed, instead Mr. Bowman purchased his seeds from a grain elevator, what are commonly called “commodity seeds”. The grain elevator would contain the harvest from local farmers, the majority of whom would have likely used Monsanto’s Roundup Ready soybeans. In their licensing agreement Monsanto authorizes growers to sell second-generation seed to local grain elevators as a commodity, without restricting grain elevators’ subsequent sales of that seed. Biofortified notes that “the natural and foreseeable purpose of commodity soybean grain is for feed, processing into oil and textured vegetable protein, etc – the purpose is to enter the food supply, not to be planted“.

Mr. Bowman planted these commodity seeds, without a licensing agreement, and used Roundup as a weed control on this second crop. In choosing Roundup Mr. Bowman ensured that only soybeans with the resistance trait (i.e., Roundup Ready soybeans) would flourish in the crop. According to The Atlantic, Mr. Bowman repeated this practice from 2000 through 2007, and unlike his first planting, he saved the seeds (those selected by him through his use of Roundup to contain the Roundup Ready trait) from his subsequent harvests and replanted them as additional second-crops in later years.

Enter the Courts

Monsanto filed suit against Mr. Bowman claiming that by not buying seeds for each generation he had infringed upon their patents associated with genetically engineered soybeans, which contain patented biotechnology that enables the plants to tolerate glyphosate, the active ingredient in Roundup. Mr. Bowman contended that Monsanto’s patent rights were exhausted once he bought the seeds and that use of progeny seeds is an expected use of the product. Monsanto responded that in the case of self-replicating technologies the patent extends to the technology, in this case, herbicide resistance, rather than the seed itself.

The Federal Circuit upheld a District Court decision awarding Monsanto $84,456.20 in damages for violation of their patented technology, reasoning that Monsanto’s herbicide resistant technology was covered by patent regardless of whether it was the original seed or a product of the original seeds. The case was taken up by the Supreme Court, where it was argued on February 19, 2013, the full transcript is available here. After the arguments were heard, many news outlets and organizations seemed to think that the decision would once again favor Monsanto, and on May 13, 2013, Justice Kagan delivered the opinion for a unanimous Court ruling in favor of Monsanto. From the opinion:

By planting and harvesting Monsanto’s patented seeds, Bowman made additional copies of Monsanto’s patented invention, and his conduct thus falls outside the protections of patent exhaustion. Were this otherwise, Monsanto’s patent would provide scant benefit.

After inventing the Roundup Ready trait, Monsanto would, to be sure, “receive [its] reward” for the first seeds it sells. But in short order, other seed companies could reproduce the product and market it to growers, thus depriving Monsanto of its monopoly. And farmers themselves need only buy the seed once, whether from Monsanto, a competitor, or (as here) a grain elevator. The grower could multiply his initial purchase, and then multiply that new creation, ad infinitum – each time profiting from the patented seed without compensating its inventor.

Innovation and Investment

This verdict is good news for innovation and investment in technology. If the courts had ruled in favor of Mr. Bowman, there would be little incentive to invest in not just agricultural biotechnology, but also other innovations in computers, medicine, and other technologies. Without protections provided by patent law, anyone could create a virtually limitless supply of patented technology, thereby eliminating the incentive to invest in research and development for fear of not recouping costs. Monsanto invested 13 years and hundreds of millions of dollars into developing herbicide-resistant seeds, and regardless of your personal feelings towards the company, they deserve to recoup and profit from their investment. 

That is not to say that the only reason to invest in research is for profit, as the President of the National Research Council of Canada would have you believe (his actual quote ”scientific discovery is not valuable unless it has commercial value“). Quite the contrary, profit is the result of doing research, and should not be the reason to do it, or invest in it. Phil Plait notes that “basic scientific research is a vast endeavor, and some of it will pay off economically, and some won’t. In almost every case, you cannot know in advance which will do which“. Basic scientific research eventually paved the way for Roundup Ready technology, and that investment and foresight, should be rewarded with patent protection. Ensuring protection for investments in innovation and technology through patent law, also ensures that basic scientific research, not just applied, can continue to be funded, and that is a good thing.

Reflections on the 6th International Symposium on Flame Retardants

A little bit too keen, I was the first one into the conference hall.

A little bit too keen, I was the first one into the conference hall at the Sir Francis Drake Hotel

As I mentioned in my previous post, I was recently in San Francisco for the 6th International Symposium on Flame Retardants. California is a fitting host for a conference on flame retardants, as their unique flammability standard, TB-117, has likely contributed to the ubiquitous contamination of humans and the environment with brominated flame retardants (BFRs), specifically the polybrominated diphenyl ethers (PBDEs). Research has shown repeatedly that PBDEs are environmentally persistent, capable of bioaccumulating in organisms, and potentially toxic. As a result of these facts, PBDEs have been banned in several jurisdictions, and industry has agreed to a voluntary phase-out. This has led replacement chemicals being used in place of the PBDEs. These replacements are less well studied than traditional BFRs, and given that they can be structurally and functionally very dissimilar there is a need for new measurement methodologies and descriptions of their environmental fate and biological activity. The efficacy of flame retardants, which are designed to increase public safety, has also recently been called to question. At this symposium the most current state of the science for flame retardants was presented, and below I highlight some of the interesting research from the various sessions.

Analytical Methods

Studying BFRs often comes with certain analytical challenges. BFRs are tricky to analyze, and given their widespread use, they have become ubiquitous, background contaminants, often showing up in blank laboratory samples. One way to minimize background contamination is to automate and contain the entire extraction procedure. Philip Bassignani of Fluid Management Systems, presented Validating multiple matrix analysis of PBDEs using pressurized liquid extraction and multi-column clean-up, where he showcased the available technology for incorporating Pressurized Liquid Extraction (PLE) and automated multi-column Clean-up as a sample prep procedures, thereby reducing many of the problems associated with traditional manual approaches, and saving loads of time. It was a very cool talk, and made me really wish that this type of instrument was available during my research.

Another problem that was touched upon in this session was the lack of analytical standards for many of these emerging flame retardants. Standards are needed so the identity of a compound can be verified. This is particularly tricky when you are not even sure what you are looking for. Such is the case when you are trying to determine what degradation products, metabolites, or unknown compounds may be in a sample. Mehran Alaee of Environment Canada presented the work Post target determination of brominated flame retardants and related compounds in American Eels captured in Eastern Canada, which was somewhat of an environmental detective story, where they were able to deduce the structure of several unknown contaminants in samples of Eel. This is accomplished by gaining an accurate mass for the unknown compound from the time of flight mass spectrometer, and then determining the possible combination of atoms that could result in that mass, then determining whether the mass spectra of that possible combination fits with the observed spectra in the sample. It is like trying to solve a puzzle, without knowing what the picture is supposed to be.

Measurements in Abiotic Media

Once the methods are developed for analyzing these flame retardants (again not an easy task), next you can go out an measure them in real samples. Rob Letcher of Environment Canada presented the paper Comparative photolytic debromination of decabromodiphenyl ether, decabromodiphenyl ethane, and tetradecabromodiphenoxybenzene flame retardants and environmental considerations, in which he highlights some of the measurements of new and relatively huge BFRs, and some of the pathways by which they can be transformed into more toxic compounds.

Measurements in Biota

In addition to measuring flame retardants in environmental samples like, air, dust, water, and sediment, it is also important to monitor these compounds in biota. The uptake of compounds from the environment into biota is known as bioaccumulation, and if the accumulation is great enough, this can result in toxic effects. Roxana Sühring of Helmholtz-Zentrum Geesthacht, Institute of Coastal Research presented work on the accumulation of flame retardants in two different species of eel, throughout their lifecycles, From glass to silver eel – brominated flame retardants and Dechloranes in European and American eels. The work was very interesting, largely in part because of the unique life-history traits of eels (future post), and the varying susceptibility to contaminants and contaminant profile during their life cycle.

Toxicology

One of the reasons for concern over flame retardants is due to their toxicity. Flame retardants tend to not be acutely toxic, but rather demonstrate a chronic toxicity, often mediated through endocrine system, as several flame retardants have structural similarities to hormones, particularly the thyroid hormones. David Volz of the University of South Carolina presented some very compelling evidence Aryl phosphate esters within a major penta-BDE replacement product induce cardiotoxicity in developing zebrafish embryos: potential role of the aryl hydrocarbon receptor, that demonstrated that some flame retardants are exerting their toxicity through the aryl hydrocarbon receptor; the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin is also mediated through this receptor.

Epidemiology

Regrettably I missed this session as I was discussing my posters with other researchers over lunch and things went long. However, the talk Associations between maternal serum PBDEs and fetal thyroid hormones: Results from the Chemicals, Health and Pregnancy (CHirP) study, looked really cool.

Exposure Pathways

Before there can be toxicity, there must be exposure. This session showed many ways (mainly dust and food) which we are being exposed to these compounds, but two of the talks were about unique occupational exposures. The first, by Anna Strid of Stockholm University looked at Exposure to brominated flame retardants during maintenance work in aircrafts. Airplanes are loaded with flame retardants, and that is probably a good thing, but continuous workplace exposure can become an issue for pilots, flight attendants, and mechanics. Another interesting and overlooked group in terms of high levels of occupational exposure, are gymnasts. Courtney Carignan of Boston University School of Public Health presented work on Gymnast exposure to flame retardants, given that much of gymnastic equipment is foam, which contains high concentration of flame retardants, levels in the air, dust and gymnasts were elevated. The work presented was just the preliminary findings and there is much more to be done, but this was really cool and will be something to keep an eye on.

Policy

The symposium concluded with talks related to how all the research that has been done can change or influence policy. One of the first challenges that will need to be addressed is to get everyone talking the same language. Andreas Rydén of Stockholm University presented A novel abbreviation standard for organobromine, organochlorine and organophosphorus flame retardants, to help get everyone on the same page, which means I will have to change all my references to TBBPA-DBPE, BEHTBP, and EHTeBB in my papers to TBBPA-BDBPE, BEH-TEB, and EH-TBB, respectively. The symposium ended with a panel discussion, which focused on whether there is a need for these flame retardants in various consumer products (e.g., insulation, couches, children’s toys and products), and the current regulatory system for flame retardants which is highly stove-piped (e.g., EPA, California Bureau of Home Furnishings, Department of Toxic Substances Control all have interests and regulations relating to flame retardants) and largely ineffective.  There was a comment from the audience that flame retardants (and other chemicals in consumer products, (e.g., PFCs, musks, nanoparticles) should be regulated just as food, drugs, and pesticides are currently. One comment that really struck me is that scientists are spending lots of time and money (often public funds), to just determine what substances are in the products we are exposed to everyday. Recently, there has been lots of excellent work by researches focused on determining what is in our couches, knowledge that industry has, but does not share because of its proprietary nature. This just seems so backwards to me.

Overall it was a great symposium filled with an almost overwhelming amount of interesting research and discourse. Flame retardants are going to be an environmental and human health issue for a long time, and forums like this symposium are crucial for helping researchers gain insights and share ideas.

Round-Up Ready: San Francisco Edition

Catch of the day at New May Wah market

Catch of the day at New May Wah market

My recent “all quiet on the cyberfront” has been due to commitments to getting ready for a trip to San Francisco for a conference on flame retardants (more on that later). In the mean time, here is a quick summary of some of the highlights of my time in San Francisco, as experienced through a sensory overload and guided by my second cousin Mary, who is celebrating a birthday today, Happy Birthday Mary!

The Smells

Spilled beer and fish at the Hyde Street Pier, the exotic smells of New May Wah Market, and the distinctive odor of The 38 Geary Bus, there is no shortage of interesting aromas in the City by the Bay.

The Tastes

A lemon tree grows on the grounds on Jacuzzi Winery

A lemon tree grows on the grounds on Jacuzzi Winery

The freshness of all the food really stands out, be it the backyard meyer lemons, the asparagus, caught that day sushi, Yuubi Japanese Restaurant, the amazing local beer Lagunitas Beer, and the wines of Sonoma valley, specifically the Jacuzzi Winery, with its knowledgeable and friendly staff.

The Feels

The photoscopes, or original moving picture show booths, with colorful content

The photoscopes, or original moving picture show booths, with colorful content at the Musee Mecanique

It is always good advice to be careful about what you touch, but at the Musée Mécanique touching and playing with all the coin operated fortune telling booths, games, and photoscopes is encouraged and awesome. The California Academy of Sciences has a stricter touching policy, but is still very cool and definitely worth a visit, particularly for the planetarium.

The Sounds

The sounds of the city, like the roar from The Giants Game, are quit once you enter Grace Cathedral, although it is difficult appreciate the quietness when all you can hear in your head is The Decemberists Grace Cathedral Hill.

The Sights

There are so many great sights in San Francisco; Muir Woods, Lands End, Bay Bridge at night, Golden Gate Bridge at anytime. These iconic images have been featured in many movies and television.

The Golden Gate Bridge at night, with planes and stars overhead

The Golden Gate Bridge at night, with planes and stars overhead

Top 5 Movies/TV Shows Based in San Francisco

  1. Full House
  2. The Rock
  3. Rise of the Planet of the Apes
  4. Homeward Bound II: Lost in San Francisco
  5. Star Trek (see next page for a nerdier breakdown of San Francisco in Star Trek) Continue reading

The Money and The Madness

The first round of the men’s NCAA basketball tournament is over, and my bracket is already pretty busted, thanks Georgetown and UCLA! Maybe I should have listened to The New Yorker when picking my bracket. They offered the following tip for picking teams in the tournament, follow the money. Citing that when schools spend a lot on flashy facilities, big-name coaches, and better recruits, they tend to do well. They note that this year, the schools in the tournament spent a combined $340,000,000 on men’s basketball, with revenues expected around $540,000,000, with the individual schools spending between $16,000,000 (Duke, a 2 seed) and $535,000 (Southern, a 16 seed) on their programs.  They created a handy infographic to help illustrate the disparity in spending between schools, as well as help track the success of that spending.

Looking at the results of the tournament with knowledge about spending, adds an extra layer of impressiveness, outrage, and excitement. It wasn’t much of a surprise that all four number 1 seeds made it through to the second round, they spend a lot of money;  $155,192 (University of Kansas), $132,911 (Louisville), $109,495 (Indiana University), and $86,460 (Gonzaga) per basketball player. The first near surprise of the tournament, was when the number 3 seeded Marquette, whose expenses are estimated at $283,871 per basketball player, nearly lost to 14 seeded Davidson, which spends $15,378 per basketball player, the fifth lowest spending team in the tournament. The first big surprise came from Harvard (14 seed), with total basketball expenses at $1,225,999 their expenses per basketball player come in at $13,365, they defeated number 3 seed New Mexico, which has total expenses of $4,448,425, or $50,797 per player. The Harvard win, their first ever in the NCAA tournament, busted a few brackets and resulted in quite a few good laughs, but wasn’t as exciting or shocking as the Florida Gulf Coast University (15 seed) upset over Georgetown (2 seed). FGCU spends $15,779 per player, whereas Georgetown spends an average of $121,756 per player, more than a $100,000 difference per player!

The final four based on tuition costs

The final four based on tuition costs

It is neat to look at how much money a school spends on their basketball program, and it is cooler when you consider how much it costs to go to those schools.The Awl ran their own version of the tournament based on tuition. Tuition at FGCU is $5,352 while going to Georgetown will set you back $40,920, putting it in the final four of the most expensive tuition in the tournament, but ultimately it falls short to Bucknell which has the highest tuition of $45,132. 

It is clear that while money may help you along the way to the tournament, and may result in a higher seeding, come game day, none of that matters anymore, and if you play like FGCU did (see below), you are going to win, regardless of much you spent to get there, and that is part of the beauty of March Madness.

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Comedy in the Age of Social Media, Part 2

Last year I had a post about the Comedy in the Age of Social Media, where I discussed twitter and podcasts as a way for comedians to reach a larger audience. Today I stumbled upon these PBS Off Book videos that look at the world of viral videos, internet comedy, and webcomics, that further explore the new ways we are consuming comedy

Having more comedy available to us is great, because even though laughter might not be the best medicine, it certainly does have its benefits. The benefits of laughter are nicely outlined on Mind the Science Gap;

  1. Increase pain tolerance and improve overall pain management.
  2. A small study have found that laughter and exposure to comedic films can be linked to lower postprandial (i.e. after a meal) blood glucose levels, and that the reduction is even greater for persons with diabetes.
  3. Several studies have detected an inverse relationship between sessions of laughter and the amount of the “stress hormone” cortisol in test subjects’ blood (more laughter = less cortisol)
  4. Multiple researchers found that watching comedic films relaxes arteries and improves blood flow, while watching dramatic or unsettling films has the opposite effect.
  5. No side-effects are associated with comedy, not even puns!

So have a little chuckle today, it’ll do you some good.

Round-Up Ready: March Madness Edition

It’s that time of the year again, March Madness! In case you aren’t sure what all the fuss is about, Rob Delaney offers a unique explainer of the madness, and this supercut from the characters of Mad Men effectively captures some of the madness.

A large part of the enjoyment of March Madness, comes from filling out a bracket, there is no shortage of advice for filling out a bracket (see here, here, here, here, and here), following the ups and downs, the Cinderellas (and all these other buzzwords), the thrill of victory and the agony of defeat (perfectly displayed in this 2006 UCLA vs. Gonzaga game) throughout the tournament. However, if for some reason the traditional bracket scheme doesn’t add enough excitement for you, Slate offers alternative ways to gamble on the tournament.

Who will be crowned the cutest animal. My money is on

Who will be crowned the cutest animal. I am going with Giraffes for the upset over Otters.

If college basketball is not your thing, there are alternative tournaments that are available that try and capitalize on the true March Madness. Be it MTV’s Musical March Madness, Vulture’s Best Sitcom of the Past 30 Years, Land Robots and Flying Drones, or Star Wars’ This is Madness Tournament, there is a bracket/tournament for everyone, especially for animal lovers. Buzzfeed is presenting Animal March Madness, which seeks to crown the next cutest animal (animals who have already been the big thing are excluded, i.e., cats, dogs, owls, pandas, dolphins, penguins, sloths, and hedgehogs). The Buzzfeed post inspired an Assistant Professor of Human Evolutionary Biology at Harvard University, Katie Hinde, to create a bracket using *simulated* head to head combat and competition among mammals, as an access point for talking about mammals.The match-ups are previewed in the video below, and here is a link to a blank bracket.

Each round/battle features a discussion of the various traits and adaptations that might serve that mammal well in the battle, for example in the third round match up between the Lion and the Polar Bear she tweets “Lion: Claws, Jaws, & Leap; Polar Bear Claws, Jaws, & Reach… & Heavier #2013MMM”, ultimate winner, The Polar Bear (Without tall grass for Lion to stalk and surprise blitz Polar Bear, lion was at a major disadvantage). This tournament combines the joys of simulated animal battle and the thrill of betting on an underdog, or naked mole rat, as the case may be. And speaking of mammals, Radiolab is running a bracket to come up with a name for our hypothetical common placental mammal ancestor. So make your picks, enjoy the tournament, and don’t feel too bad if you don’t pick a perfect bracket, at 1 in 9,223,372,036,854,775,808 (based on random selection), the odds are not in your favour.

By 2050…

There is something about the year 2050 that is appealing to futurists, policy makers, and scientists alike. The year shows up in the title of hundreds of books, countless press releases, and news articles, as the year that things hit the fan. The predictions and estimates for the future tend to be heavy on fear mongering and doomsday thinking, which will not help build a solid future, and light on practical solutions or hope. Below is just a small sampling of some of the predictions from around the web for the World in 2050

The World Population will be Larger, and the Demographics will be different

In 2050, the population of the USA is expected to top

In 2050, the population of the USA is expected to top 439 million citizens, mostly in 11 mega-regions

As the global population swells, resource depletion will be exacerbated which will have drastic effects on the climate and the earth.

Environmental Outlook Not so Good

The challenges of the growing population and changes to climate will be very evident in terms of the food supply.

Food Security Will Be an Issue

  1. Increase funding for scientific and technological research to boost agricultural production and efficiency
  2. Develop scientific policies and institutions to deal with environmental degradation caused by population growth

Unfortunately there is opposition to many agricultural innovations, and a lack of political will to deal with environmental degradation.

It isn’t all bad news for 2050

It looks like the world is going to be an interesting and different place by 2050