SCOTUS Decision on Bowman v. Monsanto Co.

Today the Supreme Court of the United States ruled on the Bowman v. Monsanto Co. case in favor of Monsanto. The Atlantic described the case as a story about technology and innovation and investment, about legal standards and appellate precedent and statutory intent, about the nature of nature and how the law ought to answer the basic question of who owns the rights to the seeds of planted seeds“.  The case centers around 75 year old* Indiana soybean farmer Vernon Hugh Bowman, and his decision to plant a second crop of soybeans. Below is a brief overview of the case and some of the implications of the verdict.

*(every article about this case needs to point out his age)

Background Information

Obligatory file photo showing a farmer holding Monsanto's Roundup Ready Soybean seeds (AP Photo/Dan Gill, File)

Obligatory file photo showing a farmer holding Monsanto’s Roundup Ready Soybean seeds (AP Photo/Dan Gill, File)

For a thorough and legalese heavy primer on the case, read the summary put together by the Cornell University Law School, here, for a less technical primer, continue reading. Mr. Bowman had originally purchased Monsanto’s Roundup Ready Soybeans and planted them as his main crop in the spring. When a farmer buys seed for planting (genetically engineered or not), that seed usually has a contract associated with it that says that the farmer can not replant the harvested grain, Mr. Bowman signed that standard licensing agreement. Up until this point everything is on the straight and narrow, but then Mr. Bowman decided to plant his second crop of soybeans later that year, but he didn’t want to pay for Monsanto’s seed, instead Mr. Bowman purchased his seeds from a grain elevator, what are commonly called “commodity seeds”. The grain elevator would contain the harvest from local farmers, the majority of whom would have likely used Monsanto’s Roundup Ready soybeans. In their licensing agreement Monsanto authorizes growers to sell second-generation seed to local grain elevators as a commodity, without restricting grain elevators’ subsequent sales of that seed. Biofortified notes that “the natural and foreseeable purpose of commodity soybean grain is for feed, processing into oil and textured vegetable protein, etc – the purpose is to enter the food supply, not to be planted“.

Mr. Bowman planted these commodity seeds, without a licensing agreement, and used Roundup as a weed control on this second crop. In choosing Roundup Mr. Bowman ensured that only soybeans with the resistance trait (i.e., Roundup Ready soybeans) would flourish in the crop. According to The Atlantic, Mr. Bowman repeated this practice from 2000 through 2007, and unlike his first planting, he saved the seeds (those selected by him through his use of Roundup to contain the Roundup Ready trait) from his subsequent harvests and replanted them as additional second-crops in later years.

Enter the Courts

Monsanto filed suit against Mr. Bowman claiming that by not buying seeds for each generation he had infringed upon their patents associated with genetically engineered soybeans, which contain patented biotechnology that enables the plants to tolerate glyphosate, the active ingredient in Roundup. Mr. Bowman contended that Monsanto’s patent rights were exhausted once he bought the seeds and that use of progeny seeds is an expected use of the product. Monsanto responded that in the case of self-replicating technologies the patent extends to the technology, in this case, herbicide resistance, rather than the seed itself.

The Federal Circuit upheld a District Court decision awarding Monsanto $84,456.20 in damages for violation of their patented technology, reasoning that Monsanto’s herbicide resistant technology was covered by patent regardless of whether it was the original seed or a product of the original seeds. The case was taken up by the Supreme Court, where it was argued on February 19, 2013, the full transcript is available here. After the arguments were heard, many news outlets and organizations seemed to think that the decision would once again favor Monsanto, and on May 13, 2013, Justice Kagan delivered the opinion for a unanimous Court ruling in favor of Monsanto. From the opinion:

By planting and harvesting Monsanto’s patented seeds, Bowman made additional copies of Monsanto’s patented invention, and his conduct thus falls outside the protections of patent exhaustion. Were this otherwise, Monsanto’s patent would provide scant benefit.

After inventing the Roundup Ready trait, Monsanto would, to be sure, “receive [its] reward” for the first seeds it sells. But in short order, other seed companies could reproduce the product and market it to growers, thus depriving Monsanto of its monopoly. And farmers themselves need only buy the seed once, whether from Monsanto, a competitor, or (as here) a grain elevator. The grower could multiply his initial purchase, and then multiply that new creation, ad infinitum – each time profiting from the patented seed without compensating its inventor.

Innovation and Investment

This verdict is good news for innovation and investment in technology. If the courts had ruled in favor of Mr. Bowman, there would be little incentive to invest in not just agricultural biotechnology, but also other innovations in computers, medicine, and other technologies. Without protections provided by patent law, anyone could create a virtually limitless supply of patented technology, thereby eliminating the incentive to invest in research and development for fear of not recouping costs. Monsanto invested 13 years and hundreds of millions of dollars into developing herbicide-resistant seeds, and regardless of your personal feelings towards the company, they deserve to recoup and profit from their investment. 

That is not to say that the only reason to invest in research is for profit, as the President of the National Research Council of Canada would have you believe (his actual quote “scientific discovery is not valuable unless it has commercial value“). Quite the contrary, profit is the result of doing research, and should not be the reason to do it, or invest in it. Phil Plait notes that “basic scientific research is a vast endeavor, and some of it will pay off economically, and some won’t. In almost every case, you cannot know in advance which will do which“. Basic scientific research eventually paved the way for Roundup Ready technology, and that investment and foresight, should be rewarded with patent protection. Ensuring protection for investments in innovation and technology through patent law, also ensures that basic scientific research, not just applied, can continue to be funded, and that is a good thing.

Frankenfoodie Friday

A different spin on the usual Foodie Friday post, today I wanted to summarize the fallout of a recent study in the journal of Food and Chemical Toxicology titled Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. The study claims to be the first long-term (two years) study into the health impact of a genetically modified (GM) tolerant maize crop, and the herbicide Roundup in Sprague-Dawley rats. Before I get into the results, just some quick background information of GM maize, Roundup, and Sprague-Dawley rats. GM maize is corn which has been genetically modified to withstand spraying with glyphosate, the active ingredient in Roundup, and is said to be a Roundup Ready crop. The goal of Roundup Ready crops is to allow the crop to be sprayed without being damaged, while surrounding weeds are destroyed. Roundup, or more specifically glyphosate, is one of the most commonly used herbicides in the agricultural and cosmetic-use industries. Sprague-Dawley rats are commonly used organisms in laboratory studies partly because of its calm demeanor and ease of handling. The average life-span of a Sprague-Dawley rat can range between 193-1100 days, during which time up to 57% of females can expect to develop tumors on a normal diet, and up to 80% of those on a fat-rich diet can expect to develop mammary tumors. This strain of rat is particularly prone to developing tumors, particularly when fed an unrestricted diet.

Back to the paper, the authors chose a 2 year duration for the study, as they were interested in the chronic effects of this diet and noted that “no regulatory authority requests mandatory chronic animal feeding studies to be performed for edible GM crops“, and that currently, approval is based on a 90-day feeding trial. They carried out their study on 10 groups, each group containing 10 male and 10 female rats. 3 groups were exposed to Roundup Ready corn (NK603) with three different proportions (11, 22, and 33%) of the corn incorporated into their diet. 3 groups were exposed to Roundup Ready corn which had been sprayed with Roundup in the field, with the same proportions in the diet as with the Roundup Ready corn alone. 3 groups were exposed to Roundup alone via their drinking water at three different concentrations of glyphosate; 50 ng/L (1.1×10-8% Roundup), 400 mg/kg (0.09% Roundup), and 2.25 g/L (0.5% Roundup) [note: the discrepancy between units is from the original paper]. This leaves only 1 control group (10 males and 10 females), which received a diet made up of 33% non-GM corn and plain drinking water. The authors took blood and urine samples and performed histological analysis of the rats’ principal organs at the end of the trial.

The authors found that in all treated groups, there were 2 – 3 times more deaths amongst the females compared to the controls by the end of the experiment. Females developed fatal mammary tumors and pituitary disorders, and males suffered liver damage, developed kidney and skin tumors and problems with their digestive system. The majority of tumors were only detected from 18 months onwards. The largest tumors were five times more frequent in females than in males and 93% were mammary tumors.These results were highlighted by very graphic photos.

Rats, and their paired mammary glands, from the treated groups, noticeably absent is the control group.

The authors conclude that the biochemical disturbances and physiological failures in the rats are the result of Roundup Ready Corn and Roundup alone. The conclusions of this paper got picked up by a lot of media outlets, where it was quickly reported that Major study proves cancer dangers of GM food, or that GM corn linked to early death in new study, or as the Daily Mail put it, Cancer row over GM foods as study says it did THIS to rats…and can cause organ damage and early death in humans.

However, it didn’t take long for other scientists to speak up about the results (the following links do a much better job than I could at describing the failings of the article, so click through for the full story). The Science Media Centre collected the opinions of many scientists regarding the findings and interpretation of the paper. NewScientist does a great job of clearly summing up the problems with the paper, in a very concise and easy to follow manner, with helpful supporting links. SciCurious gives a great technical takedown of the study at The Crux. Forbes contributor Tim Worstall calls the study rubbish, noting that every research animal in the US has been eating GM food for well over a decade, all without a catastrophic collapse of the population. One of the most scathing and insightful reviews (read: takedown) of the paper comes from Michael Grayer, who blows a gasket while describing the many failings and shortcomings of the paper, which are quickly summarized as very small sample size in the control group (10 animals), many different experimental groups, opaque and non-declared statistical methods, emotionally distressing/manipulative photos of rats, and a fairly apparent conflict of interest that goes undeclared by the lead author.

The conflict of interest of the lead author is a bit troubling as the issue of GM crops is very political, and becoming less about science. Forbes has a great article, Monsanto’s GM Corn and Cancer in Rats: Real Scientists Deeply Unimpressed. Politics, Not Science Perhaps? which highlights the political back story and interests behind this paper, its authors, and funding group. The timing of this paper, and the heated discussion surrounding it, coincides with California Proposition 37, Mandatory Labeling of Genetically Engineered Food initiative which will be on the November 6th ballot. Prop 37 would require all genetically engineered foods in California to be labeled. Gary Ruskin, campaign manager of the Yes on Proposition 37 effort, is using the study to “underscore the importance of giving California families the right to know whether our food is genetically engineered and to decide for ourselves whether we want to gamble with our health by eating GMO foods.”  The findings of the study have also found their way into the promotional material for Yes on Prop 37, which will no doubt serve to muddy up the debate.

Aside from getting people talking about GM crops, this paper is also serving a greater purpose. Understanding Uncertainty gives an excellent breakdown of the flawed statistics used in the paper, but it is able to find a silver lining, noting that it provides a fine case study for teaching a statistics class about poor design, analysis and reporting. This paper and the ensuing reaction is another great example of the need for critical reading, and reporting, of scientific articles.

Looks like the paper mentioned above is going to be retracted, which is great news, but I somehow doubt the retraction will get as much press or feature on The Dr. Oz Show, as the original publication did.

Update: June 26th 2014

Looks like the paper mentioned above has been re-published, with very little changes and without peer review, in a different journal. Once again the scientific community is criticizing their results and ethics of the authors. The Genetic Literacy Project has complied an excellent list of reactions to this new development.